Nearly a decade after impressing audiences at the 1999 Toronto International Film Festival with their engaging coming of age story Goat on Fire and Smiling Fish, filmmakers Derick and Steven Martini return to deliver this period drama following two families whose lives are profoundly affected by complex relationships, real estate woes, and Lyme disease. Set on Long Island in the late 1970s, Lymelife opens to find a suburban community swept up in fear after local resident Charlie Bragg (
Timothy Hutton) is diagnosed with Lyme disease. Charlie's tightly-wound neighbor Brenda Bartlett (Jill Hennseey) is determined not to let her gentle fifteen year old son Scott (
Rory Culkin) suffer a similar fate, and has taken to duct-taping his cuffs to ensure that he remains Lyme disease-free. Meanwhile, as Charlie convalesces, his wife Melissa (
Cynthia Nixon) goes to work for Brenda's philandering husband Mickey (
Alec Baldwin), a respected real estate developer. All the while, Melissa remains clueless to the fact that she was hired more out of lust than as a friendly favor to a neighbor in need. For years, Scott has pined after Charlie and Brenda's daughter Adrianna (
Emma Roberts), and strangely enough it seems that she's finally starting to return his affections. Tensions are running particularly high in the neighborhood lately, and when Scott's older brother Jimmy (
Kieran Culkin) arrives home on leave from the army, his confrontations with his tempestuous father Mickey threaten to trigger repercussions that will affect the lives of everyone involved. ~ Jason Buchanan, All Movie Guide