Innerspace (1987)

Synopsis
Director Joe Dante infuses this science fiction comedy with the visual razzle-dazzle and manic, goofball performances typical of his cartoon-inspired sensibilities. Navy test pilot Lt. Tuck Pendleton (Dennis Quaid) has volunteered for a highly dangerous medical experiment. A submersible craft, with Tuck at the controls, is to be shrunk down to molecular size and inserted into the body of a living rabbit. If successful, the test could result in radical breakthroughs in surgical techniques, but some high-tech thieves attempt to steal Tuck and his ship while both are in miniature form. Enter Jack Putter (Martin Short), a mild-mannered, hypochondriac retail store clerk, a nerd who suddenly finds himself injected with Tuck and his tiny ship. Now poor Jack's got to rise above his mundane existence to help an American hero get back to safety, while also trying to reunite Tuck with his beautiful estranged girlfriend Lydia (Meg Ryan). Innerspace (1987) won an Academy Award for Best Visual Effects. ~ Karl Williams, All Movie Guide